Not all cognitive change with age is disease. A recurring question across these projects is how to separate normal lifespan variation from the early signal of pathology — which is why normative modelling and large lifespan cohorts appear so often alongside the clinical datasets.
CNS Projects¶
Josh Neudorf — structural and functional connectivity changes in older age that help preserve cognitive ability, and the effects of acute sleep restriction on older adults
Sima Abbasi Habashi — why white matter hyperintensity burden progresses at very different rates across individuals as they age
Trishna Saha Detroja — sleep fragmentation, brain structure, and dementia in aging
Mohamed Abdelhack — cognitive and motor change in neurodegenerative and vascular disease affecting older Canadians
Related Resources¶
Datasets — UK Biobank, ADNI, ABCD (developmental counterpart)
Modalities — structural MRI, fMRI
Methods — normative modelling, deep learning
Related topics — Dementia, Alzheimer’s Disease